HORDB

ID: hor001696
Uniprot ID: P69145
Protein name: FMRFamide
Gene name: NA
Organism: Macrocallista nimbosa (Sun-ray clam)
Family: FARP (FMRFamide related peptide) family
Source: animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Macrocallista (genus), Veneridae (family), Veneroidea (superfamily), Venerida (order), Neoheterodontei, Imparidentia (superorder), Euheterodonta (infraclass), Heteroconchia, Autobranchia (subclass), Bivalvia (class), Mollusca (phylum), Lophotrochozoa, Spiralia, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: NA
GO BP: GO:0007218 neuropeptide signaling pathway
GO CC: GO:0005576 extracellular region

Function: Myoactive; cardioexcitatory substance. Pharmacological activities include augmentation, induction, and regularization of cardiac contraction.
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

AF-P56942-F1.pdb

hor001696_AF2.pdb

hor001696_ESM.pdb

Mass:	65343	Formula:	C29H41N7O5S
Absent amino acids:	ACDEGHIKLNPQSTVWY	Common amino acids:	F
pI:	10.55	Basic residues:	1
Polar residues:	0	Hydrophobic residues:	2
Hydrophobicity:	75	Boman Index:	-661
Half-Life:	1.1 hour	Half-Life Yeast:	3 min
Half-Life E.Coli:	2 min	Aliphatic Index	0
Instability Index:	-1135	Extinction Coefficient cystines:	0
Absorbance 280nm:	0

PubMed ID: 877582
Title: Structure of a molluscan cardioexcitatory neuropeptide.
PubMed ID: 909875
Title: Purification and characterization of a cardioexcitatory neuropeptide from the central ganglia of a bivalve mollusc.